Treatment Strategies - Competitive Catabolism

Simulation Parameters

Disease State

Adiposity (fold change) Relative to healthy lean state (1.0 = healthy, 3.0 = obese)

Additional Disease Parameter (Optional) (learn more)

Disease Parameter Fold Change Fold change for the selected disease parameter 0 = complete knockout, 1 = no change, 2 = double Parameters labled on/off only accept 1 or 0

Treatment Options

Insulin Dose (U/kg/day, long-acting) 0.2 U/kg/day Simulated dose of long-acting insulin (e.g., glargine, detemir). Range: 0-0.5 U/kg/day represents physiological to high therapeutic doses.

Ranking Variable (for sensitivity analysis) Variable used to rank parameters for treatment discovery

Auto-select Top 3 Treatments (by sensitivity analysis)

Display Options

Show Glucose

Show Insulin

Show HOMA-IR

Show Fatty Acids

Show 3-Hydroxybutyrate

Show Lactate

Additional Parameter Modifications (Optional)

Simulation Results

Configure disease state and click "Run Simulation" to identify optimal treatments.

Predict Treatment Strategies